منابع مشابه
Tissue-Resident Memory CD8+ T Cells: From Phenotype to Function
Tissue-resident memory CD8+ T cells are an important first line of defense from infection in peripheral non-lymphoid tissues, such as the mucosal tissues of the respiratory, digestive, and urogenital tracts. This memory T cell subset is established late during resolution of primary infection of those tissues, has a distinct genetic signature, and is often defined by the cell surface expression ...
متن کاملLocal immunity by tissue-resident CD8+ memory T cells
Microbial infection primes a CD8(+) cytotoxic T cell response that gives rise to a long-lived population of circulating memory cells able to provide protection against systemic reinfection. Despite this, effective CD8(+) T cell surveillance of barrier tissues such as skin and mucosa typically wanes with time, resulting in limited T cell-mediated protection in these peripheral tissues. However, ...
متن کاملSnapShot: Resident Memory T Cells
Resident memory T cells (TRM) comprise a subset of nonrecirculating memory T cells that remain positioned at common portals of reinfection. These include barrier tissues such as the mucosae and skin. TRM orchestrate the initial response to pathogens re-encountered at these locales, thereby accelerating protective immune responses.
متن کاملTissue-resident natural killer cells.
Natural killer (NK) cells kill infected and tumor cells and produce cytokines that modulate other immune cells. However, most of our current knowledge is derived from investigations of mouse splenic and human peripheral blood NK cells, "conventional" NK cells. Herein we discuss recent studies indicating that the liver contains two subpopulations of NK cells, one of which is liver-resident and b...
متن کاملBone Marrow T Cells and the Integrated Functions of Recirculating and Tissue-Resident Memory T Cells
Changes in T cell trafficking accompany the naive to memory T cell antigen-driven differentiation, which remains an incompletely defined developmental step. Upon priming, each naive T cell encounters essential signals - i.e., antigen, co-stimuli and cytokines - in a secondary lymphoid organ; nevertheless, its daughter effector and memory T cells recirculate and receive further signals during th...
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ژورنال
عنوان ژورنال: Blood
سال: 2018
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2018-99-109534